2010
- Chen EY, Yang N, Quinton PM, and Chin WC. 2010. "A new role for bicarbonate in mucus formation." Am J Physiol Lung Cell Mol Physiol 299: L542-549.
- Joo NS, Cho HJ, Khansaheb M, and Wine JJ. 2010. "Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs." J Clin Invest 120: 3161-3166.
- Muchekehu RW, and Quinton PM. 2010. "A new role for bicarbonate secretion in cervicouterine mucus release." J Physiol 588: 2329-2342.
- Chapman AL, Morrissey BM, Vasu VT, Juarez MM, Houghton JS, Li CS, Cross CE, and Eiserich JP. 2010. "Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway." J Cyst Fibros 9: 84-92.
- Vasu VT, de Cruz SJ, Houghton JS, Hayakawa KA, Morrissey BM, Cross CE, and Eiserich JP. 2010. "Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase." Free Radic Res.
- Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, and Hammock BD. 2010. "Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs." Eur J Pharm Sci 40: 222-238.
- Liu JY, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, and Hammock BD. 2010. "Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events." Proc Natl Acad Sci U. S. A. 107: 17017-17022.
2009
- Choi JY, Khansaheb M, Joo NS, Krouse ME, Robbins RC, Weill D, Wine JJ "Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process." J Clin Invest. 2009 May;119(5):1189-200.
- Yang J, Schmelzer K, Georgi K, and Hammock BD. 2009. "Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry." Anal Chem 81: 8085-8093.
2008
- Ianowski JP, Choi JY, Wine JJ, Hanrahan JW. "Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands." Pflugers Arch. 2008 May 29.
- Christianson JC, Shaler TA, Tyler RE, Kopito RR. "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD." Nat Cell Biol. 2008
Mar;10(3):272-82.
2007
- Ianowski, J.P., J.Y. Choi, J.J. Wine, and J.W. Hanrahan. 2007. "Mucus secretion by single tracheal submucosal glands from normal and CFTR knock-out mice." J Physiol. 580.1: 301-314
- Gaggioli V, Schwarzer C, Fischer H. 2007. "Expression of Nox1 increases cellular acid production but not proton conductance." Arch Biochem Biophys 459, 189-196.
- Schwarzer C, Illek B, Suh JH, Remington SJ, Fischer H, Machen TE. 2007. "Organelle redox of CF and CFTR-corrected airway epithelia." Free Radic Biol Med, 5;43:300-16.
- Hybiske K, Fu Z, Schwarzer C, Tseng J, Do J, Huang N, Machen TE. 2007. "Effects of cystic fibrosis transmembrane conductance regulator and DF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia." Am J Physiol 293:L1250-60.
- Choi JY, Joo NS, Krouse ME, Wu JV, Robbins RC, Ianowski JP, Hanrahan JW, Wine JJ. 2007. "Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis." J Clin Invest. 117:3118-27
2006
- DeLaBarre, B., J.C. Christianson, R.R. Kopito, and A.T. Brunger. 2006. "Central pore residues mediate the p97/VCP activity required for ERAD." Mol Cell 22:451-462.
- Xu, X., D. Zhang, H. Zhang, P.J. Wolters, N.P. Killeen, B.M. Sullivan, R.M. Locksley, C.A. Lowell, and G.H. Caughey. 2006. "Neutrophil histamine contributes to inflammation in mycoplasma pneumonia." J Exp Med 203:2907-2917.
2005
- Lee, H., M. Pespeni, J. Roux, P.A. Dennery, M.A. Matthay, and J.F. Pittet. 2005. "HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats." Faseb J 19:287-289.
- Pittet, J.F., H. Lee, M. Pespeni, A. O'Mahony, J. Roux, and W.J. Welch. 2005. "Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90." J Immunol 174:384-394.
- Reddy, M.M., X.F. Wang, M. Gottschalk, K. Jones, and P.M. Quinton. 2005. "Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism." J Membr Biol 203:151-159.
- Roux, J., H. Kawakatsu, B. Gartland, M. Pespeni, D. Sheppard, M.A. Matthay, C.M. Canessa, and J.F. Pittet. 2005. "Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway." J Biol Chem 280:18579-18589.
- Salinas, D., P.M. Haggie, J.R. Thiagarajah, Y. Song, K. Rosbe, W.E. Finkbeiner, D.W. Nielson, and A.S. Verkman. 2005. "Submucosal gland dysfunction as a primary defect in cystic fibrosis." Faseb J. 19:431-433.
- Wang, X., C. Lytle, and P.M. Quinton. 2005. "Predominant constitutive CFTR conductance in small airways." Respir Res 6:7 (12 pages).
2004
- Chen, Y., Y.H. Zhao, T.B. Kalaslavadi, E. Hamati, K. Nehrke, A.D. Le, D.K. Ann, and R. Wu. 2004. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues." Am J Respir Cell Mol Biol 30:155-165.
- Fischer, H., C. Schwarzer, and B. Illek. 2004. "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel." Proc Natl Acad Sci U. S. A. 101:3691-3696.
- Salinas, D.B., N. Pedemonte, C. Muanprasat, W.F. Finkbeiner, D.W. Nielson, and A.S. Verkman. 2004. "CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor." Am J Physiol Lung Cell Mol Physiol 287:L936-943.
- Schwarzer, C., T.E. Machen, B. Illek, and H. Fischer. 2004. "NADPH Oxidase–dependent acid production in airway epithelial cells." J. Biol. Chem. 279:36454-36461.
- Tong, Z., B. Illek, V.J. Bhagwandin, G.M. Verghese, and G.H. Caughey. 2004. "Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line." Am J Physiol Lung Cell Mol Physiol 287:L928-935.
- Verghese, G.M., Z.Y. Tong, V.J. Bhagwandin, and G.H. Caughey. 2004. "Mouse Prostasin* Gene Structure, Promoter Analysis, and Restricted Expression in Lung and Kidney." Am J Respir Cell Mol Biol 30:519-529.
- Wang, X.F., M.M. Reddy, and P.M. Quinton. 2004. "Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts." Exp Physiol 89:417-425.
2003
- Frank, J., J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C.M. Canessa, et al. 2003. "TGF-beta 1 decreases expression of the epithelial sodium channel alpha ENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK 1/2-dependent mechanism." J Biol Chem 20:20.
- Howard, M., H. Fischer, J. Roux, B.C. Santos, S.R. Gullans, P.H. Yancey, and W.J. Welch. 2003. "Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function." J Biol Chem 278:35159-35167.
- Swanson, B., R. Savel, F. Szoka, T. Sawa, and J. Wiener-Kronish. 2003. "Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay." J Microbiol Methods 52:361-366.
2002
- Jacob, T., R.J. Lee, J.N. Engel, and T.E. Machen. 2002. "Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa." Infect Immun 70:6399-6408
2001
- Chandy, G., M. Grabe, H.P. Moore, and T.E. Machen. 2001. "Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells." Am J Physiol Cell Physiol 281:C908-921.
- Machen, T.E., G. Chandy, M. Wu, M. Grabe, and H.P. Moore. 2001. "Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH." Jop 2:229-236.
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Moving Research Forward
As researchers answer questions on the molecular and biochemical mechanisms of CF, more questions follow as the complexity of this disease is encountered. This is why the dedication of CFRI in supporting research is so important.
CFRI’s programs—the Elizabeth Nash Memorial Fellowship and the New Horizons Campaign—have funded research such as Pseudomonas and its interaction with the epithelium, alternate signaling pathways that induce chloride channel function, the role of calcium-activated chloride channels in the lung, antioxidants and the CF lung, mucous gland regulation and secretion, and CF lung microbial populations and their role in susceptibility to infection—all critical issues for CF patients.
The grants we receive are high quality, peer reviewed, and thoughtfully evaluated by Research Advisory Committee members before final funding recommendations are made. My only regret as chair of the RAC is that we don’t have enough funds to support all the proposals we receive.
CFRI Research Advisory Committee
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