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Current Research

Elizabeth Nash Memorial Fellowship

Forest Rohwer, PhD, Robert Quinn, PhD, San Diego State University, Identifying Metagenomic Signals Characteristic of Cystic Fibrosis Exacerbation Onset

Ron Kopito, PhD, Chris Walczak, PhD, Stanford University, Analysis of a functional network of ubiquitin-proteasome dependent degradation of CFTRΔF508

Walter E. Finkbeiner MD, PhD, Carolin Boecking, MD, University of California San Francisco, Development and Characterization of Novel 3D Airway Cell Models for CF Research

Wito Richter, PhD, Elise Blanchard, PhD, University of California San Francisco, Inhibition of Type 4 phosphodiesterases as a therapeutic approach for CF

Joanne Engel, MD, PhD, Travis Ruch, PhD, University of California San Francisco, The Role of CFTR in a Novel Pathogen Sensing Mechanism

New Horizons Research

AKM Shamsuddin, PhD, University of California San Diego, Ion Transport Properties in Human Native Small Airways

Ning Yang, MD, PhD, University of California San Diego, Correcting Abnormal Cystic Fibrosis Mucus with CFTR-independent HCO3- Secretion

Jeff Wine, PhD, Stanford University, A Little CFTR Goes a Long Way: Accurate, in vivo Readout of CFTF Function

Paul Beringer, PharmD, University of Southern California, Mechanism of macrocyclic peptide regulation of Pseudomonas-induced pulmonary inflammation

Jason Rock, PhD, University of California San Francisco, Tmem 16a as a target for treatment of chronic lung infection in CF patients

Special Circumstances

Sara Modlin, Touro University, College of Osteopathic Medicine, Investigating the Beneficial Effects of Osteopathic Manipulative Treatment in the Prevention of Cystic Fibrosis Distal Intestinal Obstructive Syndrome

Moving Research Forward

As researchers answer questions on the molecular and biochemical mechanisms of CF, more questions follow as the complexity of this disease is encountered. This is why the dedication of CFRI in supporting research is so important.

CFRI’s programs—the Elizabeth Nash Memorial Fellowship and the New Horizons Campaign—have funded research such as Pseudomonas and its interaction with the epithelium, alternate signaling pathways that induce chloride channel function, the role of calcium-activated chloride channels in the lung, antioxidants and the CF lung, mucous gland regulation and secretion, and CF lung microbial populations and their role in susceptibility to infection—all critical issues for CF patients.

The grants we receive are high quality, peer reviewed, and thoughtfully evaluated by Research Advisory Committee members before final funding recommendations are made. My only regret as chair of the RAC is that we don’t have enough funds to support all the proposals we receive.

CFRI Research Advisory Committee
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