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Current Research

Elizabeth Nash Memorial Fellowship

Stanford University School of Medicine - Carlos E. Milla, MD and Andrey V. Malkovskiy, PhD - Post Doc Fellow,
Development of a Novel Biomarker of CFTR function

Mayo Clinic – Michael Joyner, MD and Noud van Helmond, MD, Improving Drug Delivery in Cystic Fibrosis using Exercise

New Horizons Research

Stanford UniversityJeff Wine, PhD,  A Little CFTR Goes a Long Way: Accurate, in vivo Readout of CFTR Function

University of Southern California – Paul Beringer, PharmD., Mechanism of Macrocyclic Peptide Regulation of Pseudomonas-induced Pulmonary Inflammation

University of California San Diego – Paul Quinton, PhD, Assessing the Role of Secretory and Absorptive Epithelium Lining Lung Airways

University of California San Francisco – Peter Haggie, PhD, Novel Therapeutic Approaches for Cystic Fibrosis Caused by the W1282x Premature Termination Codon

Special Circumstance

Children’s Hospital Los Angeles and the Keck School of Medicine; USC Keck School of Medicine; Pediatric Pulmonology –
 Danieli Salinas, MD, Sweat Rate Measurement for Confirmation of Cystic Fibrosis Newborn Screening

Moving Research Forward

As researchers answer questions on the molecular and biochemical mechanisms of CF, more questions follow as the complexity of this disease is encountered. This is why the dedication of CFRI in supporting research is so important.

CFRI’s programs—the Elizabeth Nash Memorial Fellowship and the New Horizons Campaign—have funded research such as Pseudomonas and its interaction with the epithelium, alternate signaling pathways that induce chloride channel function, the role of calcium-activated chloride channels in the lung, antioxidants and the CF lung, mucous gland regulation and secretion, and CF lung microbial populations and their role in susceptibility to infection—all critical issues for CF patients.

The grants we receive are high quality, peer reviewed, and thoughtfully evaluated by Research Advisory Committee members before final funding recommendations are made. My only regret as chair of the RAC is that we don’t have enough funds to support all the proposals we receive.

CFRI Research Advisory Committee Chair
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